Recently, professors Lei Guanghua, Zeng Chao and Wei Jie from the Department of Orthopedics at Xiangya Hospital of Central South University (CSU), the Key Laboratory of Aging-Related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, and the National Clinical Research Center for Geriatric Disorders teamed up to publish a series of 10 clinical and translational research findings in authoritative journals including EBioMedicine, Bone Research, Arthritis Rheumatol, Ann Intern Med, JAMA Net Open, Int J Surg, Sci Bull and ACS Appl Mater Interfaces. This series of research focuses on the risk factors, pathogenesis, clinical treatment, prognosis and new drug development of common bone and joint diseases represented by osteoarthritis, and provides new ideas for clinical prevention and treatment.
After ten years of hard work, the team has developed two prospective natural population cohort studies in the field of osteoarthritis in China through long-term and stable follow-up: “Xiangya Osteoarthritis Study” and “Xiangya Step Study”. The latest research findings based on these two studies were published in EBioMedicine as an original paper titled “Association between Gut Microbiome-related Metabolites and Symptomatic Hand Osteoarthritis in Two Independent Cohorts”. The research used the cohort “Xiangya Osteoarthritis Study” for findings, and identified the association between tryptophan metabolism disorder mediated by gut microbiota imbalance and hand osteoarthritis. Later on, in the independent cohort “Xiangya Step Study”, the association between key tryptophan metabolites and hand osteoarthritis was further validated, which provided a theoretical basis for elucidating the pathogenesis of hand osteoarthritis and exploring new targets for prevention and treatment. Professor Wei Jie, technician Yang Zidan and Doctoral student Li Jiatian are the co-first authors of the paper. Professor Lei Guanghua and Professor Zeng Chao are the co-corresponding authors. Professor Zhang Yuqing, Professor Zhang Weiya, Professor Michael Doherty, Physician Yang Tuo, Physician Yang Yuanheng, Associate Professor Li Hui, Associate Professor Wang Yilun, Doctoral student Wu Ziying and Professor Li Changjun are important co-authors of the paper.
The research findings based on “Xiangya Osteoarthritis Study” were published in Bone Research as an original paper titled “Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways”. Through single-cell transcriptome sequencing, the research identified for the first time the cell subpopulations that may play a key role in the pathogenesis of hand osteoarthritis, which were later validated based on the “Xiangya Osteoarthritis Study” and “UKBiobank”, providing a new direction for elucidating the cellular and molecular mechanisms of hand osteoarthritis. Associate Professor Li Hui, Dr. Jiang Xiaofeng, and Attending Physician Xiao Yongbing are the co-first authors of the paper. Professor Lei Guanghua, Professor Zeng Chao and Professor Wei Jie are the co-corresponding authors. Professor Zhang Yuqing, Professor Zhang Weiya, Professor Michael Doherty, Dr. Jacquelyn Nestor, Professor Li Changjun, Doctoral student Ye Jing, Assistant Researcher Sha Tingting and Associate Chief Physician Lyu Houchen are important co-authors of the paper.
(First Reviewer: Zhang Xu, Second Reviewer: Wang Xuan, Third Reviewer: Li Yin)
Source: Xiangya Hospital Authors: Wang Ning and Xie Dongxing
Original article link: https://news.csu.edu.cn/info/1003/157662.htm
